GLP-1 Protocol
by @peplog
Standard GLP-1 receptor agonist protocol for metabolic health and weight management. Emphasizes proper dose titration to minimize side effects. Compatible with most other peptide stacks.
Community
Protocol Contents
Literature
2studies linked · foundational research for this protocol
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Wilding JPH, Batterham RL, Calanna S, et al.
The STEP 1 trial establishing semaglutide 2.4mg efficacy — the clinical basis for this protocol's dosing recommendations.
Two-Year Effects of Semaglutide in Adults with Overweight or Obesity (STEP 5)
Garvey WT, Batterham RL, Bhatta M, et al.
Long-term data supporting sustained use — weight loss maintained over 2 years with continued cardiometabolic benefits.
Discussion
3 comments
PSA: If you're new to this protocol, PLEASE follow the titration schedule. I track a group of ~200 users and the ones who jump straight to 0.5mg+ have 3x the dropout rate due to side effects. Start at 0.25mg for at least 4 weeks.
Wish I'd seen this earlier. I titrated at the standard 4-week schedule and the 0.5mg jump was rough. 8 weeks at 0.25 would have been smarter.
For those combining this with a recovery stack — I've been running Semaglutide alongside BPC-157 with no interaction issues. Just make sure you're eating enough protein since the appetite suppression can make it easy to undereat.