Semaglutide
Metabolic & GLP-1
A GLP-1 receptor agonist originally developed for type 2 diabetes management. Widely used for weight management through appetite suppression and metabolic regulation. Requires careful dose titration.
Community
Reported Adverse Effects
Based on 5,231 user reports
Community Consensus
“Effective for weight management at 0.5–2.4mg/week with diet and exercise”
“GI side effects are common, especially during dose titration periods”
“Slow dose titration (4+ weeks per step) significantly reduces side effects”
Literature
3studies linked · all open in new tab
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Wilding JPH, Batterham RL, Calanna S, et al.
2.4mg weekly semaglutide resulted in 14.9% mean body weight reduction vs 2.4% with placebo over 68 weeks (STEP 1 trial, n=1,961).
Semaglutide 2.4 mg Once a Week in Adults with Overweight or Obesity, and Type 2 Diabetes (STEP 2)
Davies MJ, Bergenstal R, Bode B, et al.
In adults with T2D and overweight/obesity, semaglutide 2.4mg achieved 9.6% weight loss vs 3.4% with placebo, with sustained HbA1c improvements.
Two-Year Effects of Semaglutide in Adults with Overweight or Obesity (STEP 5)
Garvey WT, Batterham RL, Bhatta M, et al.
Weight loss with semaglutide 2.4mg was sustained over 2 years with a mean reduction of 15.2%, with continued cardiometabolic benefits.
Discussion
6 comments
Anyone else dealing with nausea on the 0.5mg dose? Was totally fine on 0.25mg for 4 weeks but the step-up has been rough. Day 3 post-injection is the worst.
That's exactly why I stopped — documented the whole thing on my profile. The nausea at 0.5mg was unbearable for me personally. Some people titrate more slowly with success though.
Try splitting the dose — 0.25mg twice per week instead of 0.5mg once. Several people in my tracking group have had success with that approach. Same weekly total, fewer peaks.
I spent 8 weeks on 0.25mg before stepping up and had zero nausea at 0.5mg. The standard 4-week titration might be too aggressive for some people. Patience pays off.
Month 3 on Semaglutide. Down 14lbs, appetite is well controlled. No significant sides at 0.5mg. I will say everyone's tolerance is different — my partner had to stop at the same dose due to nausea. Genetics probably play a role.
Great point about individual variation. There's emerging research on GLP-1 receptor polymorphisms affecting both efficacy and side effect profiles. Worth keeping an eye on.